Recent evidence indicates that the allele ε4 of the apolipoprotein E (ApoE), a well … What does HA stand for? The present paper summarized these recent advances in understanding the hippocampal asymmetries at molecular, circuit and functional levels. HA abbreviation stands for Hippocampal Asymmetry. … Therefore, the current study was conducted in a rat pilocarpine model of acquired epilepsy. Moreover, the left‐right asymmetry of the hippocampus receives less research attention. The Increased hippocampal shape asymmetry and volumetric ventricular asymmetry in autism spectrum disorder. The hippocampus is a part of the limbic system and plays an important role in short-term memory, the formation of new memories, the retrieval of older memories, spatial navigation, learning, contextual-fear conditioning, and neuroendocrine regulation. Hippocampal sclerosis is a frequent pathologic finding in community-based dementia.Hippocampal sclerosis can be detected with autopsy or MRI. He noted that such asymmetry of effective hippocampal connections explains one of the most frequent disorders of consciousness caused by local … To address hippocampal asymmetry, a repeated-measures analysis of variance was conducted, with APOE group as the between-group factor and hemisphere (right vs. left hippocampus) as the within-subjects repeated measure. After adjustment for age, sex, and IQ, right (but not left) hippocampal volumes were negatively associated with memory, executive function, and semantic fluency. The hippocampus shows a significant increase in asymmetry longitudinally and both hippocampus and amygdala show a significantly higher asymmetry cross-sectionally concurrent with disease severity above and beyond an ageing effect. Despite the increasing prevalence of ASD and the breadth of research conducted on the disorder, a conclusive etiology has yet to be established and controversy still exists surrounding … Hippocampal sclerosis (HS) is a neuropathological condition with severe neuronal cell loss and gliosis in the hippocampus, specifically in the CA-1 (Cornu Ammonis area 1) and subiculum of the hippocampus. asymmetry for the hippocampus. There is atrophy of the brain cells. Hippocampal volumes are presented in Table 1.There was a significant main effect for diagnosis for right hippocampal volume (F(1,66) = 9.63, p = .003) and total hippocampal volume (F(1,66) = 8.73, p = .004).The mean volume of the left hippocampus was also smaller in the PTSD group but this difference did not reach significance (F(1,66) = 3.35, p = 0.07). Hippocampal asymmetry and temperament appear to be relatively independent of one another, with neurobiology accounting for a small amount of variance in temperament (Whittle et al., Reference Whittle, Yucel, Fornito, Barrett, Wood and Lubman 2008). The hippocampal asymmetry remained un- changed in three of the children who were reexamined after 2 years. The observed NAA hippocampal asymmetry indicates increased neuronal density and/or functional integrity in the right compared to left hippocampus. Here we present hippocampal asymmetry data from the Dallas Heart Study determined by automated methods and its relationship to age, sex, and ethnicity. reporting hippocampal asymmetry normalized by total hip-pocampalvolume(Table1andFig1).However,wealsoreported hippocampal asymmetry normalized by the larger of the 2 hip-pocampi because this reflects the evaluation when attempting to a Hippocampal Asymmetry a a. The hippocampal sulcus was open, bi- or unilaterally, in 39 fetuses. The oldest was at GW 32. The sulcus was closed at GW 21 at the earliest, unilaterally. In 26/63 fetuses (41%), the deepening or closure of the hippocampal sulcus or hippocampal inversion was asymmetric; in 23 fetuses, the right side developed faster. The structural asymmetry of bilateral hippocampus in mammals has been well recognized. Recent findings highlighted the accompanying functional asymmetries, as well as the molecular differences of the hippocampus. The hippocampus is known to be critical for learning and memory, the putative role of hippocampus dysfunction remains poorly understood in preterm neonates. Moreover, the left‐right asymmetry of the hippocampus receives less research attention. In this article, meta‐analyses are designed to determine the extent of hippocampal atrophy in MCI and AD, and to evaluate the asymmetry pattern of the hippocampal volume in control, MCI, and AD groups. Abstract. BACKGROUND AND PURPOSE: Asymmetry of the hippocampus is regarded as an important clinical finding, but limited data on hippocampal asymmetry are available for the general population. There was no significant population-level asymmetry for the amygdala. Autism spectrum disorder (ASD) is a prevalent and fast-growing pervasive neurodevelopmental disorder worldwide. However, little information is now available about the VIP receptor types which may be involved in the behavioral effects of the peptide. It was first described in 1880 by Wilhelm Sommer. The findings show a bilateral hippocampal volume loss in MCI and the extent of atrophy is less than that in AD. By comparing the left and right hippocampal volume, a consistent left‐less‐than‐right asymmetry pattern is found, but with different extents in control (ES, 0.39), MCI (ES, 0.56), and AD (ES, 0.30) group. © 2009 Wiley‐Liss, Inc. Recent findings highlighted the accompanying functional asymmetries, as well as the molecular differences of the hippocampus. Hippocampal atrophy is often associated with memory-loss illnesses like dementia. Hippocampi are asymmetrical in children and adults, where the right hippocampus is larger. Abstract. MATERIALS AND METHODS: 3D … What is the abbreviation for Hippocampal Asymmetry? Particularly, hemispherical asymmetry of the hippocampus has been well-noted, either structurally or functionally. An analysis of variance using sex and rearing history as between-group variables showed no significant main effects or interaction effects on the AQ scores; however, males were more strongly lateralized than Most experts agree that it plays a significant role in both memory and in spacial awareness, though the details of its involvement are widely disputed. 1,2 The hippocampus is a specific region producing new neurons throughout adult life, and hippocampal formation has been considered an … Results revealed that both the hippocampus and the amygdala are reliably asymmetrical structures in normal adults, with larger right hippocampal (D = 0.21, p <.001) and right amygdala (D = 0.09, p <.01) volumes. Indeed, asymmetrical extra-hippocampal gray matter loss related to hippocampal atrophy can encompass the ipsilateral and contralateral hemisphere, particularly the contralateral hippocampus, more pronounced in patients with left MTLE . How the preterm birth impairs the hippocampal development, Hippocampal atrophy is a condition characterised by degeneration of the hippocampus. Hippocampus is a complex brain structure that undergoes severe sclerosis in TLE. https://www.frontiersin.org/articles/10.3389/fpsyt.2018.00226 Results revealed that both the hippocampus and the amygdala are reliably asymmetrical structures in normal adults, with larger right hippocampal (D = 0.21, p.001) and right amygdala (D = 0.09, p.01) volumes. The hippocampus is a complex brain structure and undergoes severe sclerosis and gliosis in temporal lobe epilepsy (TLE) as the most common type of epilepsy. The key features of the TLE may be reported in chronic animal models of epilepsy, such as pilocarpine model. Anatomical asymmetries, however, have been only superficially studied in Alzheimer's disease. High signal intensities on T,-weighted images were seen beneath the cortex-white matter junction in the frontal and temporal lobes of five (28%) children, one of whom also had a hippocampal asymmetry… To date, no literature has confirmed that hippocampal asymmetry is evident at birth. The Hippocampal Volume Asymmetry Report provides: •Colored brain images captured from MRI • Detailed measurements of the left and right hippocampus, and the asymmetry between them, which is important in the assessment of TLE Additional analyses indicated that differences in MRI magnet field strength and slice thickness values might differentially contribute to volumetric asymmetry estimates. Asymmetry of brain structures is common to many species and is even present in utero. Furthermore, gender differences have been observed in normal hippocampal asymmetry, but this has not been examined in neonates. Some developmental, pathological, and dementing diseases are associated with alterations in normal anatomical asymmetries. Increased lines of evidence indicate an essential role for the hippocampus in differentiating food related cues, a function required for adequate energy regulation . Asymmetry of the hippocampus and amygdala in MRI volumetric measurements of normal adults - Volume 10 Issue 5 - OTTO PEDRAZA, DAWN BOWERS, ROBIN GILMORE The time scale of hippocampal involvement in retrieving memories, particularly those more remote, is still a matter of debate. Numerous studies have reported a smaller hippocampal volume in Alzheimer's disease (AD) patients than in aging controls. Second, standard stimulation of the left, rather than right, amygdala does lead to an asymmetric accumulation of 7SC in the left hippocampus one month post kindling (left/right: 1.10 ± 0.03; n=6), indicating that complex accumulation is stimulation-dependent and not due to some unrecognized, inherent hippocampal asymmetry. Methods: Hippocampal volumes, the hippocampal asymmetry index, and cognitive functioning were assessed in 120 nondemented adults with long duration type 2 diabetes. The development of the hippocampus, including the hippocampal sulcus and the inverted hippocampal formation, was often asymmetric (26/63 = 41%), and in a great majority of the asymmetric cases, the right side (23/26 = 88%) had developed faster. Some propose that the hippocampus is not involved in the retrieval of remote memories, whereas others assert that it is necessary for memory retrieval in perpetuity. It plays a role in information processing and the reproductive cycle and is involved in Alzheimer disease. Brain hemispheric specialization is among the central features of functional cortical organization in humans (Goldberg et al., 2013) and less lateralization is usually associated with better cognitive ability (Catani et al., 2007). However, in mild cognitive impairment (MCI), the results are inconsistent. The majority of the sample displayed left greater than right hippocampal asymmetry (which is the reverse of the expected direction seen with normal aging). Here we present hippocampal asymmetry data from the Dallas Heart Study determined by automated methods and its relationship to age, sex, and ethnicity. Increased asymmetry was also associated with poorer cognitive test scores and with increased cortical atrophy. • 2-DE based proteomic technique was employed and the proteome maps were compared. Based on longitudinal asymmetry measures we subsequently study the progression from mild cognitive impairment to dementia, demonstrating that shape asymmetry in hippocampus, amygdala, caudate and cortex is predictive of disease onset. To characterize asymmetry from a molecular perspective and to unravel the possible reasons of less seizure threshold in the left side, we compared left and right hippocampus proteome in control rats. Some of the differently expressed proteins between two laterals of the control hippocampus were identified to be involved in dopamine and polyamine regulation ( Table 1 ). The structural asymmetry of bilateral hippocampus in mammals has been well recognized. 1. Results: The majority of the sample displayed left greater than right hippocampal asymmetry (which is the reverse of the expected direction seen with normal aging). We observed that the right hippocampus was wider along its lateral side in … asymmetric. After adjustment for age, sex, and IQ, right (but not left) … HC asymmetry. Recently, Monterrey et al. Hippocampal atrophy causes memory deprivation and spatial disorientation. PTSD is associated with reduction in hippocampal volume and abnormalities in hippocampal function. Hippocampal asymmetry has received less attention, but potentially could indicate lateralised differences in vulnerability to trauma. Functional magnetic resonance imaging was used to examine the effect of remoteness on … Volume analysis indicated a large normative asymmetry between left and right hippocampus (R > L), and shape analysis allowed us to visualize the normative asymmetry pattern of the hippocampal surfaces. either enlargement or asymmetry), which occurred more frequently in twin pairs with ASD (N = 18 pairs) than in control twin pairs (N = 10 pairs), however, these findings have not yet been replicated in larger samples. The hippocampus (plural: hippocampi) or historically the cornu Ammonis, is an important component of the human brain, situated in the temporal lobe. It is one of the characteristic features of hippocampal sclerosis and Alzheimer’s disease. On … The senior author of the Brain paper, Reuter explains, “Several studies have indicated that Alzheimer’s has different effects in different sub-structures of the hippocampus … BACKGROUND AND PURPOSE: Asymmetry of the hippocampus is regarded as an important clinical finding, but limited data on hippocampal asymmetry are available for the general population. (2017) reported incidental findings of hippocampal asymmetry in twin pairs with ASD (N = 15), as well as ventricular abnormalities (i.e. • The asymmetric behavioral effect of VIP on first place could be associated with the different distribution and/or affinity of VIP receptors in the left and right hippocampal CA1 area. • Some proteins showed asymmetric expression related to the mechanisms underlying TLE. surviving infants. The present study employed meta-analytic procedures to provide a systematic analysis of the normal population parameters of hippocampal and amygdala volumetric asymmetry as well as the absolute intrahemispheric volumes of these structures in normal adults. The hippocampus is an extension of the cerebral cortex and is located in the medial temporal lobe. • Pilocarpine induced epilepsy changes hippocampal asymmetry. The morphological
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